Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Perceived feasibility, facilitators and barriers to incorporating point-of-care testing for SARS-CoV-2 into emergency medical services by ambulance service staff: a survey-based approachArticle Published on 2022-11-032022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] Accuracy acquisition ambulance service Analysis approach assessments assistant Care Characteristics clinical decision clinical utility collected COVID-19 criteria current elicit Emergency emergency situation facilitator feasibility feasible Follow-up healthcare services indicated Lateral flow device majority medical service molecular diagnostics Perceived point-of-care qualitative data Qualitative research. rapid SARS-CoV-2 testing required response risk stratification SARS-CoV-2 SARS-CoV-2 test Sensitivity and specificity supported survey to define unlikely while [DOI] 10.1136/bmjopen-2022-064038 PMC 바로가기
Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort studyArticle Published on 2022-11-012022-11-15 Journal: The Lancet. Respiratory Medicine [Category] SARS, 변종, 치료기술, [키워드] accelerate Alpha assessment assumption Bayesian Cohort cohort study Community Contact correlation Course COVID-19 COVID-19 case determine diagnosed early diagnosis eight eligible enrolled Evidence Final Guidance Hierarchical High-resolution household index cases Infection infection control Infectious virus initial IQR Isolation kinetic Lateral flow device LFD median Older Onset participant PCR positive PCR-confirmed plaque-forming unit post-symptom onset Probability quantified real-world data recruitment reduced released RT-PCR SARS-CoV-2 Self-isolation sensitivity Seven study population suggested Support survival Symptom symptom onset Symptoms the median the SARS-CoV-2 to define Transmission upper respiratory tract variant viral growth Viral load viral replication Viral RNA viral RNA load viral shedding virus were assessed [DOI] 10.1016/S2213-2600(22)00226-0 PMC 바로가기
Efficacy and safety of nitazoxanide in treating SARS-CoV-2 infection: a systematic review and meta-analysis of blinded, placebo-controlled, randomized clinical trialsArticle Published on 2022-11-012022-11-15 Journal: European Journal of Clinical Pharmacology [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval addition anti-inflammatory effect antiparasitic antiviral activity blinded clinical benefit continuous variable COVID-19 D-dimer D-dimer level death dichotomous variable Disease progression Effect effect size Efficacy and safety element eligibility enrolled Evidence Frequency ICU admission in vitro individual Inflammation Invasive mechanical ventilation lactate dehydrogenase LDH magnitude Meta-analysis Mild moderate Moderate COVID-19 nitazoxanide no difference Patient patients peer-reviewed performed Placebo placebo-controlled positive positive RT-PCR Primary outcome randomized clinical trial RCT RCTs receiving reducing reduction in reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. secondary outcome serum biomarker SMD standardized mean difference systematic review tested to define treat treated Viral load WBC were used White blood cell with COVID-19 [DOI] 10.1007/s00228-022-03380-5 PMC 바로가기
Application of a Decision Tree Model to Predict the Outcome of Non-Intensive Inpatients Hospitalized for COVID-19Article Published on 2022-10-112022-11-15 Journal: International Journal of Environmental Research an [Category] 진단, [키워드] Accuracy application applied approach Blood clinical aspect clinician coronavirus disease COVID-19 decision Disease progression evaluate haematochemical parameters Health help Immunoglobulin information Inpatient intensive care units International machine learning Model normalized outcome outcomes parameter Patient patients with COVID-19 physician prediction predictor Prognostic markers prognostic markers. Prospective Study Prothrombin time repeated Research Retrospective study risk of death sensitivity specificity threshold to define tree worsening [DOI] 10.3390/ijerph192013016 PMC 바로가기
ARDS in the time of corona: context and perspectiveArticle Published on 2022-10-012022-11-16 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory distress ARDS COVID-19 disease endothelial infections mutants Perspective Respiratory failure severe COVID-19 syndrome therapeutic therapy to define Treatment Ventilator-induced lung injury ventilator-induced lung injury. [DOI] 10.1152/ajplung.00432.2021 PMC 바로가기
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review
In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy CalculationsArticle Published on 2022-09-142022-11-15 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] AAK1 addition Anti-COVID-19 Anti-SARS-CoV-2 Activity applied binding binding free energy binding pattern calculation candidate Combination complexes computational modeling digoxin drug drug repositioning drugs Dynamics energy Enzymes evaluated exhibited FDA-approved drug Free greater in silico inhibitor inhibitors methodology molecular molecular docking molecular dynamic simulations. MPro niclosamide ouabain PLPro Proscillaridin protease Protein provide RdRP repositioning RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 main protease screened suggested target targets tested to define [DOI] 10.3390/molecules27185988 PMC 바로가기
Cutaneous reactions after COVID-19 vaccination in Turkey: A multicenter studyArticle Published on 2022-09-012022-11-16 Journal: Journal of cosmetic dermatology [Category] COVID19(2023년), SARS, 두창, 수두, 치료기술, 홍역, [키워드] Adverse reaction anaphylaxis Autoimmune disease Autoimmunity BNT162b2 clinics CoronaVac COVID-19 vaccination COVID-19 vaccines cross-sectional cutaneous reaction Dermatology dose first dose Frequency herpes zoster inactivated individual injection less Local local reaction multicenter patient population Pfizer/BioNTech presenting Rash reaction Reactions required SARS-CoV-2 second dose systemic systemic adverse reaction systemic reaction the patient therapeutic intervention to define triggered triggering Turkey vaccination Vaccine Vaccines [DOI] 10.1111/jocd.15209 PMC 바로가기
Aerosol Generation During Otologic SurgeryObservational Study Published on 2022-09-012022-10-05 Journal: Otology & neurotology : official publication of th [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome aerosol Aerosol generation aerosol-generating procedures average Concentration concentrations coronavirus cough coughing ENhance Factor Generation help identify measure occur Operating room Otologic outcome Particle pathogen Pathogens Prospective Study quantified recorded reduce reduced required significantly higher Spread suction surgery to define Total was measured were recorded were used [DOI] 10.1097/MAO.0000000000003591 PMC 바로가기 [Article Type] Observational Study